Acute kidney injury (AKI) is increasing in incidence among patients undergoing endovascular therapy for critical limb ischemia (CLI), with chronic kidney disease and heart failure the strongest risk factors for AKI, investigators concluded.
An analysis of data from the National Inpatient Sample (NIS) database showed that the AKI rate of patients undergoing endovascular therapy for CLI in the United States rose from 5.6% of procedures in 2003 to 17.9% of procedures in 2012, Anand Prasad, MD, Associate Professor of Medicine at the University of Texas Health Science Center at San Antonio, and collaborators reported in Catherization and Cardiovascular Intervention. The rate of AKI requiring dialysis (AKI-D) rose from 0.5% to 1.2% during the same period. The trends were statistically significant.
Dr Prasad’s team identified diabetes, CKD, and heart failure, and diabetes as independent risk factors for AKI. The presence of these comorbidities, compared with their absence, was significantly associated with approximately 3.0-fold, 2.2-fold, and 1.3-fold increased odds of AKI, respectively.